Human pathogenic virus-associated pseudolymphomas and lymphomas with primary cutaneous manifestation in humans and animals.
Title | Human pathogenic virus-associated pseudolymphomas and lymphomas with primary cutaneous manifestation in humans and animals. |
Publication Type | Journal Article |
Year of Publication | 1998 |
Authors | Wagner M., Rose V.A., Linder R., Schulze H.J., Krueger G.R. |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
Volume | 27 |
Issue | 5 |
Pages | 1299-308 |
Date Published | 1998 Nov |
Publication Language | eng |
ISSN | 1058-4838 |
Keywords | Animals, Herpesviridae, Herpesviridae Infections, Humans, Lymphoma, B-Cell, Lymphoma, T-Cell, Cutaneous, Pseudolymphoma, RNA Virus Infections, RNA Viruses, Skin Diseases, Skin Neoplasms, Virus Diseases |
Abstract | The etiologic role of viruses in cutaneous lymphoproliferative disorders is still controversial. In benign cutaneous pseudolymphomas of the human skin, human T-cell leukemia/lymphoma virus (HTLV) type I (HTLV-I), varicella zoster virus, Epstein-Barr virus (EBV), and human herpesvirus (HHV) 6 (HHV-6) are the viruses most often identified, whereas in malignant lymphoproliferation human immunodeficiency virus type 1 (HIV-1), HTLV-I/II, and EBV are more common. Coinfections with more than one virus species have occurred in a number of cases. HHV-8 in association with a lymphoproliferative lesion appears to be indicative of a malignant cutaneous lymphoma rather than of pseudolymphoma. Negative results are of no diagnostic value because of the relatively low number of virus-positive cases: a considerable proportion of studies (with a large number of subjects) have documented virus-negative findings. Perhaps with the exception of HIV-1, findings of viral infections seem to indicate secondary rather than primary infections. Reports on animal models associated with human pathogenic viruses are scarce. |
DOI | 10.1086/514992 |
PubMed Link | |
Alternate Journal | Clin. Infect. Dis. |